Mesna uses, side effects & warnings drugs mesna effects, dosage, interactions london cancer guidelines. It is used either by mouth or injection into a vein learn. Inh Sintesis Proteica L asparaginasa (e. coli) Erwinasa (erwinia crisanteni) efectos adversos de la quimioterapia. Alquilantes Ciclofosfamida Ifosfamida Tiotepa. Enfermedad cardiovascular severa. Hipersensibilidad conocida a ningún estradiol o a mostazas nitrogenadas. Ifosfamida. Presentación: 1g.

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Pharmacheck Pharmacological Prospect General field: Pharmaceuticals Source text – English Pharmacokinetics: Prednisolone is rapidly and apparently almost completely absorbed after oral administration; it reaches peak plasma concentrations after hours. There is, however, wide inter-subject variation, suggesting impaired absorption in some individuals.

Plasma half-life is about 3 hours in adults and somewhat less in children. Its initial absorption, but not its overall bioavailability, is affected by food. Prednisolone has a biological half-life lasting several hours, making it suitable for alternate-day administration regimens. Prednisolone shows dose dependent pharmacokinetics, with an increase in dose leading to an increase in volume of distribution and plasma clearance. The degree of plasma protein binding determines the distribution and clearance of the free and pharmacologically active drug.

Thus, reduced doses are necessary in patients with hypoalbuminaemia. Prednisolone is metabolised primarily in the liver to a biologically inactive compound.

Quimioterapia para el cáncer de testículo

Liver disease prolongs the half-life of Prednisolone and, if the patient has hypoalbuminaemia, also increases the proportion of unbound drug and may thereby increase adverse effects.

Prednisolone is excreted in the urine as free and conjugated metabolites, together with small amounts of unchanged Cistitus. Significant differences in the pharmacokinetics of Prednisolone amongst menopausal women have been described. Consecuentemente, en pacientes con hipoalbuminemia, se requieren dosis disminuidas. Medical general Source text – English There are risks and hazards related to the performance of any surgical procedure.

The potential always exists for infection, hemorrhage, blood clots in veins or lungs, allergic reaction, medication reaction and even death. I also realize that the following risks and hazards may occur in connection with this particular procedure: These problems may ifosfamidda further surgical procedures, which may or may not cistitiss them. I hereby give permission to my hemorrabica or any assistant he may deem appropriate, to photograph the intended surgical site for diagnostic purposes and to enhance the medical record.

I further authorize my physician to use these heomrragica for teaching purposes. Anesthetic agents or any other medications can be harmful to the fetus of a pregnant woman. General anesthesia should be avoided during pregnancy whenever possible. I hereby state that I am not pregnant and accept the responsibility of making this determination before the procedure or surgery hereby authorized. Smokers are ifoxfamida to have a significantly higher risk of post-operative wound healing problems and complications, as well as intra-operative and post-operative bleeding.

Patients should discontinue smoking for several weeks before and after surgery. Although it helps to stop for several weeks before and after surgery, this does not eliminate the increased risk resulting from long-term smoking. I am aware that I will be given pre-operative narcotic and sedative medications and that the effects of these drugs will not subside by the time I am discharged. Some drowsiness may continue throughout the remainder of the day following surgery.


Operation of a motor vehicle is not advised for 24 hours after any drug is administered, nor should any important hemogragica be made. I understand that because of the potential effects narcotics may have, it is recommended that a legal responsible adult drive me home and stay with me for at least 24 hours after my procedure or surgery or longer if I remain sedated, etc.

I agree to follow the instructions given me by my physician to the best of cistiis ability before, during, and after cistktis surgical procedure. I understand that patient responsibility, proper performance of the postoperative care and regular return office visits are critical to the success of the operation.

Quimioterapia by Johana Zambrano on Prezi

I acknowledge that I have read and filled out the patient registration and medical history form fully and correctly to the best of my knowledge, and that the information that I have supplied is correct. My physician has fully explained in terms clear to me the nature of the procedure to be performed, the foreseeable or common risks and complications, alternative methods of treatment, as well as what I may experience if recovery is uneventful.

I have read this document or have had it read to me and I understand its contents. I hereby give my unrestricted informed consent for the surgical procedure. La anestesia general debe ser evitada durante el embarazo siempre que sea posible. Translation for Lomography Spain Microsite General field: Staying true to yourself is so important.

When we deny our needs, our wants and our desires, we stifle the beauty and creativity within.

It is important to listen to your gut, to show up for yourself in every way possible. We were born with intuition for a reason – and I think when we listen to our natural human instincts, we can find happiness more easily. How can we ever grow? We have to be open to these moments, they are all there if you allow for the space. When we have the space to be who we really are, and we are not afraid, we flourish.

Permanecer fiel a uno mismo es muy importante. Cuando negamos nuestras necesidades, anhelos y deseos, sofocamos la belleza y la creatividad internas.

Es importante escuchar a tu interior y estar para ti mismo de todas las formas posibles. No creo que las mujeres deban temer a mostrar su verdadero ser.

Cuando tenemos lugar para ser quienes realmente somos, y no tememos, florecemos. Pharmacological Insert General field: Mucolytic agent, Detoxifying agent for antineoplastic treatment urotoxicity of oxazaphosphorine Mesna was developed as a prophylactic agent, used to prevent and reduce the urothelial toxicity haemorrhagic cystitis induced by oxazaphosphorine alkylating agents such as ifosfamide or cyclophosphamide.

Analogous to the physiological cysteine-cystine system, following intravenous administration, mesna is rapidly and easily converted by autoxidation to its only metabolite, disodium 2,2′-dithio-bisethane sulphonate mesna disulphide, dimesna forming a disulphide link.

what is mesna

Mesna disulphide remains in the intravascular space and is rapidly delivered to the kidney. In the renal tubular epithelium a considerable proportion of mesna disulphide is again reduced to a free thiol compound, presumably mediated by glutathione reductase. Acrolein or other urotoxic oxazaphosphorine metabolites are detoxified by chemical reaction with the free thiol compound i.

The first and most important step towards detoxification is the reaction of mesna with the double bond of acrolein, resulting in the formation of a stable thioether which can be detected in the urine by chromatography. In the second step, mesna reduces the speed of degradation of the 4-hydroxy metabolite in the urine.


A relatively stable, non-urotoxic condensation product from 4-hydroxy cyclophosphamide or 4-hydroxy ifosfamide and mesna is formed.

As a result of this chemical interaction, mesna inhibits the degradation of 4-hydroxy cyclophosphamide or 4-hydroxy ifosfamide and hence the formation of acrolein. The presence of this intermediate chemical species can be detected by chromatographic urinalysis Pharmacokinetic properties: Mesna, a free thiol, is easily and rapidly transformed by auto-oxidation into its only metabolite mesna-disulphide dimesna.

Dimesna remains in the intravascular compartment and is quickly transported to the kidneys. In the epithelium of renal tubuli, dimesna is again reduced to the free thiol compound, which is then able to react chemically in the urine with toxic oxazaphosphorine metabolites. Elimination being almost exclusively renal starts immediately after administration. Excretion is as the free thiol mesna in the first 4 hours after a single dose and almost exclusively as the disulphide dimesna thereafter.

Renal elimination is almost complete after approximately 8 hours. Eschatology Translation General field: Esoteric practices Source text – English I am sure you understand Mr. All of us have been tempted, at times, to give our students something from a higher course. There is enough for any student to digest and use in the particular course they are studying.

Your work is to teach your students how to reason, and thereafter demonstrate what they have learned. Such teachers are always successful; for the visible fruits following this good work are so gratifying to the student, that he cannot refrain from telling others; and soon there will be a well-beaten path to such a teacher, fiosfamida matter where he be located.

Tales maestros son siempre exitosos; ya que los frutos visibles subsecuentes a este buen trabajo, son tan gratificantes para el estudiante, que este no puede abstenerse de contarle a otros. Thank you for your interest in my profile! My name is Gloria. I am a native Spanish speaker and a fluent English speaker.

I specialize in Medical translation, but I also do high quality General Translation, Transcreation, and Transcription. I am highly qualified to do Medical translation. I went to Medicine School in one of the top Universities of my country, La Salle University, for a period of three full years.

I can translate any medical text from any medical specialty. So far, now working as a freelancer, I have successfully translated 30 extensive pharmacological inserts for a Canadian company; 50 medical letters for an ENT and Plastic Surgery Office in Los Angeles, CA, US; and worked more than hours for a popular and trendy Artistic Photography company. All of these, and a few more, in only 9 months.

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My experience also includes doing professional and skillful interpretation for the largest interpreting company in the U. Regarding my education and other working experience, it is important to mention that I also lived and studied in the US for a considerable time. My excellent command of the English language has also allowed me to work successfully in the past as an English teacher and as a Bilingual Executive Assistant and Receptionist for over 7 years, altogether.

Thank you for your time! I look forward to work for you very soon! Profile last updated Sep 5, More translators and interpreters: Or create a new account. View Ideas submitted by the community.