Equilibrio de Gibbs-DonnanFisiología general y biofísicaLic. NutriciónKarla Keesoon Irais Carrera ➀ ➁ ➂ ➃ ➄ ➅ ➆. ➇. Español: Equilibrio de Gibbs – Donnan. Date. Source, Own work. Author, Biezl. Other versions. Image: Equilibrio de Gibbs Donnan. El líquido corporal se divide en intracelular y extracelular. El líquido intracelular se subdivide en dos compartimientos: intravascular.

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Efecte de Gibbs-Donnan

To neutralize the negative charges within the cell, cations flow in, which increases the osmotic pressure inside relative eqiilibrio the outside of the cell.

From Wikipedia, the free encyclopedia. I n vivoion balance does not equilibriate at the donjan that would be predicted by the Gibbs-Donnan model, because the cell cannot tolerate the attendant large influx of water. This page was last edited on 28 Eqhilibrioat The negative charge in the cell and ions outside the cell creates a thermodynamic potential; if damage occurs to the brain and cells lose their membrane integrity, ions will rush into the cell to balance chemical and electrical gradients that were previously established.

Equilkbrio Gibbs—Donnan effect also known as the Donnan’s effectDonnan lawDonnan equilibriumor Gibbs—Donnan equilibrium is a name for the behaviour of charged particles near a semi-permeable membrane that sometimes fail to distribute evenly across the two sides of the membrane.

The Donnan equilibrium is prominent in the triphasic model for articular cartilage proposed by Mow and Lai, as well as in electrochemical fuel cells and dialysis.

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In many instances, from ultrafiltration of proteins to ion exchange chromatography, the pH of the buffer adjacent to the charged groups of the membrane is different from the pH of the rest of the buffer solution.

File:Gibbs-donnansvg – Wikimedia Commons

Note that Sides 1 and 2 are no longer in osmotic equilibrium i. Negatively charged molecules within cells create a fixed charge density, which increases intracranial pressure through the Donnan effect. The presence of a charged impermeant ion for example, a protein on one side of a membrane will result in an asymmetric distribution of permeant charged ions.

Because small cations are attracted, but are not bound to the proteins, small anions will cross capillary walls away from the anionic proteins more readily than small cations. The solutions may be gels or colloids as well as solutions of electrolytesand as such the phase boundary between gels, or a gel and a liquid, can also act as a selective barrier.

The membrane voltage will become zero, but the chemical gradient will still equilibro. Donnan effect on chloride ion distribution as a determinant of body fluid composition that allows action potentials to spread via fast sodium channels.

equilibrio de gibbs-donnan

The electric potential arising between two such solutions is called the Donnan potential. Retrieved from ” https: A contribution to physical-chemical physiology].

The increased osmotic pressure forces water to flow into the cell and tissue swelling occurs. By using this site, you agree to the Terms of Use and Privacy Policy. The Donnan effect may explain why some red blood cells do not have active sodium pumps; the effect relieves the osmotic pressure of plasma proteins, which is why sodium pumping is less important for maintaining the cell volume.


Because there is a difference in concentration of ions on either side of the membrane, the pH may also differ when protons are involved. Some ionic species can pass through the barrier while others cannot. Physical chemistry Colloidal chemistry.

Archived from the original on Brain tissue swelling, known as cerebral oedema, results from brain injury and other traumatic head injuries that can increase intracranial pressure ICP. Views Read Edit View history.

Fixed negative charge and the Donnan effect: Annals of the New York Academy of Sciences. The opposing Donnan effects cause chloride ions to migrate inside the donnann, increasing the intracellular chloride concentration.

When the charged groups are positive acidicthen they will repel protons so that the pH will be higher than the surrounding buffer. ATP pumps maintain a negative membrane potential even though negative charges leak across the membrane; this action establishes a chemical and electrical gradient. Ein Beitrag zur physikalisch-chemischen Physiologie” [The theory of membrane equilibrium and membrane potential in equliibrio presence of a non-dialyzable electrolyte. When tissue cells are in a protein-containing fluid, the Donnan effect of the cytoplasmic proteins is equal and opposite to the Donnan effect of the eqilibrio proteins.