CLASSIFICATION OF ANTIHYPERLIPIDEMIC DRUGS PDF

Antihyperlipidemic Drugs. c h a p t e r atherosclerosis bile acid sequestrants catalyst cholesterol high-density lipoproteins (HDL). HMG-CoA. Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are called lipid-lowering drugs . Contents. 1 Classes. Established. 2 Research; 3 References; 4 See also. Chapter 18 Antihyperlipidemic Agents LEARNING OBJECTIVES Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics.

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By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease. Describe some new drug classes useful in the treatment of hyperlipidemia and atherosclerosis. Pharmacokinetic of Ezetimibe Metabolized in the small intestine and liver via glucuronide drugw a Phase II reactionwith subsequent biliary and renal excretion.

Their half-lives range from 1. They should not be used in children or teenagers.

Lipid-lowering agent

Clinically, the choice of an agent will depend on the patient’s cholesterol profilecardiovascular riskand the liver and kidney functions of the patient, evaluated against the balancing of risks and drugw of the medications.

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Adverse effect of statins Transient, and minor abnormality of liver function tests Myopathy and rhabdomyolysis disintegration or dissolution of muscle and elevation of muscle enzymes creatine hosphokinaseCPK: Omega-3 marine triglycerides Maxepa contain the triglyceride antlhyperlipidemic of two polyunsaturated fatty acids derived from oily fish.

Because these drugs increase biliary cholesterol excretion, there is a predisposition to the formation of gallstones. Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics anyihyperlipidemic on the structure and mode of action Define HMG-CoA and its role in hyperlipidemia Define the pharmacophoric requirements of the statin class of antihyperlipidemics Describe some antihyperlipidemics obtained from fermentation process Describe the cholesterol biosynthetic pathway and its significance Define PPAR?

Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

Anti Hyperlipidemic Drugs DrNajlaa. They have no place in treating hypercholesterolaemia. These drugs are often given in combination with other antihyperlipidemic drugs.

Serum VLDL and chylomicrons are increased. Alpha- tocopherol acetate vitamin E Has no effect on lipid levels but is a powerful antioxidant. Presentation Description No description available. Plasma total cholesterol and LDL-cholesterol fall to attain a maximum effect 1 month after therapy. Because of a circadian rhythm to LDL-receptor synthesis, statins are a little more effective if given in the evening rather than in the morning.

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List of Antihyperlipidemic agents – Generics Only –

Describe some antihyperlipidemics obtained from fermentation process. Administration of aspirin prior to taking niacin decreases the flush, which is prostaglandin mediated. Define the pharmacophoric requirements of the statin class of antihyperlipidemics.

Pharmacokinetic of Fibric acid derivatives: Fibrates enhance the effect of co-administered oral Anticoagulants. Hyperuricemia and gout Niacin inhibits tubular secretion of uric acid Impaired glucose tolerance Hepatotoxicity.

From Wikipedia, the free encyclopedia. These drugs are often given in combination with other antihyperlipidemic drugs PowerPoint Presentation: Patients with moderate to severe hepatic insufficiency should not be treated with ezetimibe.

Niacin amtihyperlipidemic acid Mechanism of action: Adverse effect of statins: Views Read Edit View history. Diabetes Mellitus with one of the primary hyperlipidaemias PowerPoint Presentation: Antidotes Contrast media Radiopharmaceuticals Dressings Senotherapeutics.

Mechanism of action of statins: Describe the cholesterol biosynthetic pathway and its significance. Mechanism of action of statins PowerPoint Presentation: