Chandipura virus (CHPV), initially thought to be an orphan virus, was later reported to cause sporadic cases of fever with arthralgia, Reye’s syndrome, and. Chandipura virus (CHPV; genus Vesiculovirus, family Rhabdoviridae) is an emerging tropical pathogen with a case fatality rate of 55 to 75% that predominantly. Chandipura virus: A virus that causes fever, symptoms similar to those of flu, and acute encephalitis (inflammation of the brain). Chandipura virus was first.

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Neuropathogenesis by Chandipura virus: None, Conflict of Interest: Chandipura virus CHPV has been contributing to the rising number of premature deaths due to acute encephalitis syndrome for over a decade in India. CHPV belongs to the family Rhabdoviridae. Neuropathogenesis of Chandipurra has been well established but the exact route of entry into the central nervous system CNS and the triggering factor for neuronal death are still unknown. Rabies virus and vesicular stomatitis virus, which are related closely to CHPV, enter the CNS retrogradely from peripheral or olfactory neurons.

The stress granules produced in response to cellular stress chandipkra been implicated in viral replication and ROS generation, which stimulates neuronal death.

Advances in Virology

Both these phenomena cohesively explain the neuropathogenesis and neurodegeneration following CHPV infection. Acute encephalitis syndrome outbreaks in India—an ongoing puzzle. A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, inassociated with Chandipura virus.

Nipah virus- associated encephalitis outbreak, Siliguri, India. Emerg Infect Dis ; Changing landscape of acute encephalitis syndrome in India: Natl Med J India ; Indian J Med Res ; Chandipura virus induces neuronal death through Fas- mediated extrinsic apoptotic pathway. Chandipura virus perturbs chaneipura homeostasis leading to neuronal apoptosis.

Neuro-invasion of Chandipura virus mediates pathogenesis in experimentally infdected mice. Int J Clin Exp Pathol ;6: Balakrishnan A, Mishra AC. Immune response during acute Chandipura viral infection in experimentally infected susceptible mice. Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, Complete genome sequences of Chandipura and Isfahan vesiculoviruses.


Structure of the low pH conformation of Chandipura virus G reveals important features in the evolution of the vesiculovirus glycoprotein. Ability of the matrix protein of vesicular stomatitis virus to suppress beta interferon gene expression is genetically correlated with the inhibition of host RNA and protein synthesis. A vesiculovirus in human epidemics. Vertical and venereal transmission of Chandipura virus Rhabdoviridae by Aedes aegypti Diptera: J Med Entomol ; An emerging tropical pathogen.

Venereal transmission of Chandipura virus by Phlebotomus papatasi Scopoli. Am J Trop Med Hyg ; First isolations of arboviruses from phlebotomine sand flies in West Africa. Experimental transmission of Chandipura virus by Phlebotomus argentipes diptera: Vectorial capacity of Culex gelidus Theobald mosquitoes to certain viruses of public health importance in India. J Vector Borne Dis ; Griffin DE, Metcalf T.

Clearance of virus infection from the CNS.

Curr Opin Virol ;1: Advances in viral transneuronal tracing. J Neurosci Methods ; The vomeronasal chemosensory system as a route of neuroinvasion by herpes simplex virus. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo.

Chandipura virus

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Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Role of lipids in virus replication. Cold Chanipura Harb Perspect Biol ;3: Virus infections in the nervous system.

Cell Host Microbe ; Cytokine levels in Chandipura virus associated encephalopathy in children. Scand J Infect Dis ; Microglial activation induces neuronal death in Chandipura virus infection.

Liou GY, Storz P. Reactive viruw species in cancer. Free Radic Res ; ROS effects on neurodegeneration in Alzheimer’s disease and related disorders: On environmental stresses of ionizing radiation.


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Chandipura Virus: an emerging tropical pathogen.

Annu Rev Immunol ; Int J Cell Biol ; Antioxidative defences are modulated differentially in three freshwater teleosts in response to ammonia-induced oxidative stress. Reduced serum non-enzymatic antioxidant defense and increased lipid peroxidation in schizophrenic patients on a hypocaloric diet. An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases. Int J Mol Sci ; Effects of EGb Ginkgo biloba extract on mitochondrial function and oxidative stress.

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Mol Cell Chamdipura ; Cell death and endoplasmic reticulum vkrus Disease relevance and therapeutic opportunities. Nat Rev Drug Discov ;7: Oxidative stress during viral infection: Free Radic Biol Med ; Induction of stress granule-like structures in vesicular stomatitis virus-infected cells.

Cgandipura Virol ; Advanced Search Users Online: How to cite this article: Ghosh S, Basu A. An acute encephalitis syndrome in India. How to cite this URL: Endemic zones of Chandipura virus in India.

The dots represent the endemic regions in India affected by Chandipura virus. The map of India was adapted from the Geography Blog http: Click here to view. Structure of Chandipura virus. Chandipura virus has a rodshaped structure, which is chandi;ura of the family Rhabdoviridae.

Elucidating the Interacting Domains of Chandipura Virus Nucleocapsid Protein

The outer envelope consists of glycoprotein G and host-derived lipid membrane. The viral RNA and envelope are connected through the matrix protein M. The genome is a single-stranded RNA having a negative helical turn.

The RNA genome is associated with three other viral proteins known as nucleoprotein Nphosphoprotein P and large protein L forming the ribonucleoprotein complex.