BIOASSAY OF INSULIN BIOASSAY OF D-TUBOCURARINE MERITS OF BIOASSAY DEMERITS OF BIOASSAY REFRENCES. is being done through. Bioassay, official method, adrenaline, digitalis, d-tubocurarine, heparin, insulin, oxytocin, gonadotropin, chorionic gonadotropin, urokinase, streptokinase. Second 4 x 4 latin square bioassay was performed using a series: with a The presence of d-tubocurarine was demonstrated in the Peruvian.

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Acetylcholine contraction is recorded on slow moving drum for 90 sec. Each rabbit is placed in a holder with its head protruding outside. Have a nice day.

WordPress Embed Customize Embed. The head should be freely movable. The potency of test sample is calculated from the standard curve. In order to view it, please contact the author of the presentation. Blood Supply It has several sources for arterial blood supply.

Saturday, 12 May Bioassay of D-Tubocurarine. They mainly respond to the acetyicholine released from motor neuron terminal. Bioassay of D-Tubocurarine 1. Two similar contractions with the same concentration of acetylcholine are obtained. Rabbits recover immediately from the effect of curarization.

Those rabbits which received the standard sample on the first day will be given test sample on the second day of expt.


PHARMACOLOGY: Bioassay of D-Tubocurarine

Use in Pharmacology The Rectus Muscle of frog is used in the screening of parasympatholytic agents. Injection should be given at a rate of 0. Minimum 8 rabbits are used. Receptors The rectus abdominis muscle of frog mainly rich of Nicotinic receptor. The presentation is d-tubocuarine added In Your Favorites.

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Numerous small segmental contribution coming from lower inter costal arteries. College of Pharmacy, Ahmedabad.

Jyotirmoy Das Choudhury M. It is also useful for bioassay of Acetylcholine. Upload from Desktop Single File Upload. They are divided into two groups each containing 4 rabbits.

Helps to flexing lumbar spine. Ringer Solution 11 Components Amount gm Nacl 6.


The percentage reduction at each dose levels is calculated and log dose response curve of nioassay standard drug is plotted. Automatically changes to Flash or non-Flash embed.

Mean dose which produces head drop of the test sample is compared with the mean dose of standard preparation. Functions It is an important postural muscle.

Cross-over test is carried out to minimise biological error due to animal variation. Infusion is continued till the rabbit will not be in a position to hold its head erect or there will be no response by focussing light on the eyes d-tubocuraarine the neck gets elongated and toneless.


Suitable dose of d-tubocurarine is 0. Newer Post Older Post Home. Presentation Description No description available. Blood supply to Rectus muscle. Go to Application Have a question?

You do not have the permission to view this presentation. Share to Twitter Share to Facebook. Head drop after injection. The total amount of test sample required to d-tubocirarine the endpoint is compared with the total amount of the standard sample required to produce similar endpoint.

-dtubocurarine head drop method for the bioassay of d-tubocurarine. Conclusion Rectus abdominis muscle of frog has various importance in pharmacology. The muscle is stabilized for min. I enjoy, result in I found exactly what I used to be looking for.

Animals should be free from disease, obtained from a healthy colony and should be accustomed with the experimental procedure. Functions of Rectus muscle.

Rectus abdominis muscle is a paired muscle running vertically on each side of the anterior wall. Pharm 1 st semester Phamacology Under the Guidance of Mr. Plays an important role in breathing It helps to keep internal organ intact.